منابع مشابه
Genetic Modification of T Cells
Gene transfer technology has advanced rapidly from simple physical-chemical laboratory methods in the 1970s and 1980s to the sophisticated viral and nonviral methods currently in clinical practice. Herein, we review 4 gene transfer methodologies applied in human gene therapy clinical trials transferring chimeric antigen receptors into T cells for the treatment of B-cell malignancies. The 4 meth...
متن کاملGenetic modification of T cells redirected toward CS1 enhances eradication of myeloma cells.
PURPOSE Our goal is to test whether CS1 could be targeted by chimeric antigen receptor (CAR) T cells to treat multiple myeloma (MM). EXPERIMENTAL DESIGN We generated a retroviral construct of a CS1-specific CAR and engineered primary human T cells expressing the CAR. We then tested the capacity of CS1-CAR T cells to eradicate human MM tumor cells in vitro, ex vivo, and in vivo using orthotopi...
متن کاملGenetic modification of somatic stem cells
Some of the illnesses that plague man kind are directly related to our genes. Severe genetic disorders with no current therapeutic options—immuno deficiencies, haemophilia, thalassaemia, muscular dystrophies and cystic fibrosis, for example—could potentially be treated with gene therapy, which uses genetic informa tion to correct a mutation or to provide new functions for human cells. the ai...
متن کاملGenetic modification of human embryonic stem cells.
Abbreviations: Ad: adenovirus, bFGF: basic fibroblast growth factor, BMP: bone morphogenetic protein, CNS: central nervous system, ES: embryonic stem, FACS: fluorescence activated cell sorting, HIV: human immunodeficiency virus, ICM: inner cell mass, LIF: leukemia inhibitory factor, MEF: mouse embryonic fibroblast, RNAi: RNA interference, SCNT: somatic cell nucleus transfer, UTR: untranslated r...
متن کاملGenetic modification of chicken germ cells
Over the past two decades numerous reports have demonstrated that the genetic modification of poultry genomes has great potential for improving poultry production; moreover, it may be used as a powerful tool for the production of industrial proteins. To date, transgenic techniques have been established for generating transgenic birds that express recombinant human proteins in hen eggs, as well ...
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ژورنال
عنوان ژورنال: Biomedicines
سال: 2016
ISSN: 2227-9059
DOI: 10.3390/biomedicines4020009